IMMUNODERMATOLOGY IN RARE AUTOIMMUNE SKIN DISORDERS

Abstract

Immunodermatology is the bridge between, dermatology and immunology in a bid to articulate the mechanisms and management options used in the treatment of the rare autoimmune dermatological disorders.  A mixed-methods experimental research into a disease(s) like linear IgA disease, dermatomyositis, and pemphigus vulgaris is provided with the help of a systematic clinical-immunological framework.  The patients were tested by direct immunofluorescence, histological biopsies, immunopathological profiling through molecular and serological testing and detailed dermatological evaluation.  According to cytokine profiling and gene expression analysis by the RT-qPCR of TNF-a and IL-6, higher levels were observed in patients that had substantial activity of the disease.  The identities of the BRCA1 and FOXP3 genes expression were significantly correlated with the treatment response.  Statistical modeling confirmed the correlations of immunological profiles with clinical results, and qualitative interviews with dermatologists and patients unveiled critical therapeutic barriers and adherence barriers.  The integrated methodology allowed accurate disease classification, individualized immunosuppressive therapy and achievement of successful longitudinal monitoring.  As it can be seen in the work-flow of the methodology (Fig. 1), the diagnostic and treatment improvement that is iterative in immunodermatology becomes adaptable to the precise demands of an individual patient.  The given work will be a combination of molecular diagnostics and personalized clinical care contributing to the use of immunodermatological models in the treatment of complicated autoimmune skin diseases.